Doctors
describe acne as
a disease of the pilosebaceous units (PSUs). Found over most of the
body, PSUs consist of a sebaceous gland connected to a canal, called a
follicle, that contains a fine hair (see "Normal Pilosebaceous Unit"
diagram, below). These units are most numerous on the face, upper
back, and chest. The sebaceous glands make an oily substance called
sebum that normally empties onto the skin surface through the opening
of the follicle, commonly called a pore. Cells called keratinocytes
line the follicle.
The hair,
sebum, and keratinocytes that fill the narrow follicle may produce a
plug, which is an early sign of
acne. The plug
prevents sebum from reaching the surface of the skin through a pore.
The mixture of oil and cells allows bacteria Propionibacterium
acnes (P. acnes) that normally live on the skin to grow in the
plugged follicles.
These
bacteria produce chemicals and enzymes and attract white blood cells
that cause inflammation. (Inflammation is a characteristic reaction of
tissues to disease or injury and is marked by four signs: swelling,
redness, heat, and pain.) When the wall of the plugged follicle breaks
down, it spills everything into the nearby skin--sebum, shed skin
cells, and bacteria--leading to lesions or pimples.
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Additional Information
About Acne
Skin Care Products
Review :From articles on skin cleansing and sun damage to
product information, we are the one-stop-shop for all of your skin
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